Metabolic control of neutrophil swarming and cluster formation (B06*)

• Subject Area: Immunology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 449437943

Neutrophil swarming and cluster formation are essential for containing lesioned tissue sites during sterile inflammation and infections. We here aim at identifying critical metabolic pathways that underlie the self-organization behavior of swarming neutrophils. With a focus on glucose metabolism, we aim at (i) mechanistically dissecting how intracellular glycogen controls neutrophil swarming, and (ii) functionally characterizing and comparing metabolism-controlled swarming responses of distinct neutrophil maturation and activation states.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 332: Neutrophils: origin, fate and function
• Applicant Institution: Universität Münster
• Project Head: Professor Dr. Tim Lämmermann, Ph.D.