Dynamic architecture of DRP1 macromolecular assemblies in mitochondrial fission (A12*)

Subject Area Biophysics
Term since 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 269925409
 

Project Description

This project aims to shed light on the molecular mechanism and dynamic behavior of DRP1 assemblies in mitochondrial fission. We will investigate the nanoscale organization of DRP1 complexes and their dynamics of interaction with mitochondria. Building on preliminary microscopy data, we will dissect the molecular mechanisms underlying mobility of DRP1 complexes and how DRP1 dynamics are functionally linked to mitochondrial fission. We will further characterize how DRP1 complexes are affected by mitochondrial adaptors and by mitochondrial stress.
DFG Programme Collaborative Research Centres
Subproject of SFB 1218:  Mitochondrial regulation of cellular function
Applicant Institution Universität zu Köln
Project Head Professorin Dr. Ana Jesús Garcia Sáez