Structural cell biology of Bunyaviruses (B03)

• Subject Area: Virology ; Biochemistry ; Structural Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512741711

Bunyaviruses cause regular outbreaks and therefore pose an imminent threat to global public health. Our understanding of the biology of these viruses is however limited. Although structures of the isolated bunyavirus L protein, a key player in viral genome replication and transcription processes, have been solved, knowledge on the broader context of these processes is needed to understand the involved host and viral factors and their spatiotemporal functional orchestration inside cells. By obtaining information on protein-protein interfaces we will be able to identify novel Achilles heels for the development of antiviral strategies.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1648: Emerging Viruses: Pathogenesis, Structure, Immunity
• Applicant Institution: Universität Hamburg
• Project Heads: Professor Dr. Kay Grünewald; Dr. Maria Rosenthal