Chronic stress-associated alterations of translation fidelity (B04)

Subject Area Biochemistry
Bioinformatics and Theoretical Biology
Cell Biology
Term since 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 520471345
 

Project Description

This project addresses the long-standing question in the field as to whether the concentrations of the translation components change with chronic exposure to oxidative stress, and how this influences translation fidelity and proteome composition. For this, we will obtain a full quantitative inventory of the translation machinery (Ignatova group) and combine that with statistical modeling (Tresch group) using cell model systems and different murine tissues.
DFG Programme Collaborative Research Centres
Subproject of SFB 1678:  Systems-level consequences of fidelity changes in mRNA and protein biosynthesis
Applicant Institution Universität zu Köln
Project Heads Professorin Dr. Zoya Ignatova; Professor Dr. Achim Tresch