Stress-dependent regulation of organellar proteome plasticity by dynamic selection of different translation initiation sites (B03)

Changing the quality and quantity of cellular and organellar proteomes, is essential for the cellular adaptation to external and internal cues. An efficient and rapid way to redirect proteins is translation from the same mRNA but using different initiation sites that alter organellar targeting information. In this project, we aim to mechanistically and genome-wide understand dynamic selection of different translation initiation sites upon redox signaling as a rapid and efficient way to achieve changes in organellar proteomes in human cells, and we want to understand how fidelity loss affects this plasticity.

DFG Programme Collaborative Research Centres

Subproject of SFB 1678:  Systems-level consequences of fidelity changes in mRNA and protein biosynthesis

Applicant Institution Universität zu Köln

Project Head Professor Dr. Jan Riemer