Pathogenesis of emerging filoviruses in humanized mice (A01)

• Subject Area: Immunology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 512741711

Highly pathogenic filoviruses, including Ebola virus (EBOV) cause severe disease in humans characterized by systemic dissemination, liver failure, and virus persistence. We will use mice with human immune systems to characterize the pathogenesis of poorly characterized filoviruses such as Tai Forest virus (TAFV) and Reston virus (RESTV). Using EBOV as reference, we will assess the capacity of TAFV and RESTV to disseminate, colonize the liver and persist. Our proposal will provide a framework to characterize the pathogenesis of newly discovered filoviruses and other unknown viruses with potential to cause disease in humans.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1648: Emerging Viruses: Pathogenesis, Structure, Immunity
• Applicant Institution: Universität Hamburg
• Project Head: Professor Dr. Cesar Munoz-Fontela