Pathogenesis of emerging filoviruses in humanized mice (A01)

Subject Area Immunology
Term since 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 512741711
 

Project Description

Highly pathogenic filoviruses, including Ebola virus (EBOV) cause severe disease in humans characterized by systemic dissemination, liver failure, and virus persistence. We will use mice with human immune systems to characterize the pathogenesis of poorly characterized filoviruses such as Tai Forest virus (TAFV) and Reston virus (RESTV). Using EBOV as reference, we will assess the capacity of TAFV and RESTV to disseminate, colonize the liver and persist. Our proposal will provide a framework to characterize the pathogenesis of newly discovered filoviruses and other unknown viruses with potential to cause disease in humans.
DFG Programme Collaborative Research Centres
Subproject of SFB 1648:  Emerging Viruses: Pathogenesis, Structure, Immunity
Applicant Institution Universität Hamburg
Project Head Professor Dr. Cesar Munoz-Fontela