Role of neph/nephrin immunoglobulin superfamily proteins in cellular guidance and the establishment of cell polarity in embryonic development

• Applicant: Professor Dr. Thomas Benzing
• Subject Area: Nephrology
• Term: from 2004 to 2010
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5446783

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• 2005. NEPH2 is located at the glomerular slit diaphragm, interacts with nephrin and is cleaved from podocytes by metalloproteinases. J Am Soc Nephrol. 16:1693-702
  Gerke, P., L. Sellin, O. Kretz, D. Petraschka, H. Zentgraf, T. Benzing, and G. Walz
  
• 2005. The slit diaphragm: a signaling platform to regulate podocyte function. Curr Opin Nephrol Hypertens. 14:211-6
  Huber, T.B., and T. Benzing
  
• 2006. Expression and function of C/EBP homology protein (GADD153) in podocytes. Am J Pathol. 168:20-32
  Bek, M.F., M. Bayer, B. Muller, S. Greiber, D. Lang, A. Schwab, C. August, E. Springer, R. Rohrbach, T.B. Huber, T. Benzing, and H. Pavenstädt
  
• 2006. Neuronal expression and interaction with the synaptic protein CASK suggest a role for Nephl and Neph2 in synaptogenesis. J Comp Neurol. 498:466-75
  Gerke, P., T. Benzing, M. Hohne, A. Kispert, M. Frotscher, G. Walz, and O. Kretz
  
• 2008. KIBRA modulates directional migration of podocytes. J Am Soc Nephrol. 19:1891-903
  Duning, K., E.M. Schurek, M. Schluter, M. Bayer, H.C. Reinhardt, A. Schwab, L. Schaefer, T. Benzing, B. Schermer, M.A. Saleem, T.B. Huber, S. Bachmann, J. Kremerskothen, T. Weide, and H. Pavenstädt
  
• 2008. Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. J Biol Chem. 283:23033-8
  Hartleben, B., H. Schweizer, P. Lubben, M.P. Bartram, C.C. Moller, R. Herr, C. Wei, E. Neumann-Haefelin, B. Schermer, H. Zentgraf, D. Kerjaschki, J. Reiser, G. Walz, T. Benzing, and T.B. Huber
  
• 2008. Nephrin mutations can cause childhoodonset steroid-resistant nephrotic syndrome. J Am Soc Nephrol. 19:1871-8
  Philippe, A., F. Nevo, E.L. Esquivel, D. Reklaityte, O. Gribouval, M.J. Tete, C. Loirat, J. Dantal, M. Fischbach, C. Pouteil-Noble, S. Decramer, M. Hoehne, T. Benzing, M. Charbit, P. Niaudet, and C. Antignac