Die Interaktion von pathogenen Neisserien mit Endothelzellen und ihre Rolle bei der Überwindung der Blut-Hirn-Schranke

• Applicant: Professor Dr. Christof Robert Hauck
• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2002 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5390418

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• 2003. "Small"-talk: Opa proteins as mediators of Neisseria-host cell communication. Current Opinion in Microbiology, 6: 43-49
  Hauck. CR. and T.F. Meyer
  
• 2004. Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. Journal of Experimental Medicine, 199: 35-46
  Schmitter, T., Agerer, F., Peterson, L., Muenzner, P., and C.R. Hauck
  
• 2004. Microscopic quantification of bacterial invasion by a novel antibody-independent staining method. Journal of Microbiological Methods, 59: 23-32
  Agerer, F., Waeckerle, S., and C.R. Hauck
  
• 2005. CEACAM engagement by human pathogens enhances cell adhesion and counteracts bacteria-induced detachment of epithelial cells. The Journal of Cell Biology, 170: 825-836
  Muenzner, P., Rohde, M., Kneitz, S., and C.R. Hauck
  
• 006. Cellular adhesion molecules as targets for bacterial infection. European Journal of Cell Biology, 85: 235-242
  Hauck, C.R., Agerer, P., Münzner, P., and T. Schmitter
  
• 2006. CEACAMs: their role in physiology and pathophysiology. Current Opinion in Cell Biology, 18:565-571
  Kuespert, K., Pils, S., and C.R. Hauck
  
• 2006. Quantification of bacterial invasion into adherent cells by flow cytometry. Journal of Microbiological Methods, 65: 301-310
  Pils, S., Schmitter, T., Neske, P., and C.R. Hauck
  
• 2007. Opa proteins of pathogenic Neisseriae initiate Src-kinase-dependent or lipid raft-mediated uptake via distinct human CEACAM isoforms. Infection and Immunity, 75: 4116-4126
  Schmitter, T., Pils, S., Weibel, S., Agerer, F., Peterson, L., Buntru, A., Kopp, K., and C.R. Hauck
  
• 2007. Profiling of bacterial adhesin-receptor recognition by soluble immunoglobulin domains. Journal of Microbiological Methods, 68: 478-485
  Kuespert, K., Weibel, S., and CR. Hauck
  
• 2008. The CEACAMl transmembrane domain, but not the cytoplasmic domain, directs internalization of human pathogens via membrane-microdomains. Cellular Microbiology, 10: 1074-1092
  Muenzner, P., Bachmann, V., Kuespert, K., and C.R. Hauck
  
• 2009. Characterizing host receptor recognition by individual bacterial pathogens. Methods Mol Biol., 470: 57-65
  Kuespert, K. and C.R. Hauck
  
• Integrin-dependent translocation of LASP-1 to the cytoskeleton of activated platelets correlates with LASP-1 phosphorylation at tyrosine 171 by Src-kinase. Thrombosis and Haemostasis, 102: 520-528
  Traenka, J., Hauck, C.R., Lewandrowski, U., Sickmann, A., Gambaryan, S., Thalheimer, P., and E. Butt
  
• 2010. CEACAMl recognition by bacterial pathogens is species-specific. BMC Microbiology, 10: 117
  Voges, M., Bachmann, V., Kammerer, R., Gophna, U., and C.R. Hauck
  
• 2010. Entry of N.meningitidis into mammalian cells requires Src family protein tyrosine kinases. Infection and Immunity, 78:1905-14
  Slanina, H., König, A., Hebling, S., Hauck, C.R., Frosch, M., and A. Schubert-Unkmeir