Dysregulation der WNT/Beta-catenin-Signalachse bei chronischer endothelialer Infektion

• Applicant: Professor Dr. Matthias Maaß
• Subject Area: Parasitology and Biology of Tropical Infectious Disease Pathogens
• Term: from 2002 to 2012
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5389455

• Final Report Year: 2010

Final Report Abstract

No abstract available

Publications

• (2004). Influence of N-glycans on the processing and the biological activity of the Nipah virus fusion protein. J.Virol. 78:7274-7278
  Moll, M., Kaufmann, A. and A. Maisner
  
• (2004). Ubiquitous activation of the Nipah virus fusion protein does not require a basic amino acid at the cleavage site. J. Virol. 78:9705-9712
  Moll, M., Diederich, S., Klenk, H.-D., Czub, M., and A. Maisner
  
• (2005). Endocytosis of the Nipah virus glycoproteins. J. Virol. 79:3865-3872
  Vogt, C., Eickmann, M., Diederich, S., Moll, M., and A. Maisner
  
• (2005). The Nipah virus fusion protein is cleaved within the endosomal compartment. J. Biol. Chem. 280:29899-903
  Diederich, S., Moll, M., Klenk, H.-D., and A. Maisner
  
• (2007). Molecular characteristics of the Nipah virus glycoproteins. Ann. N.Y. Acad. Sci. 1102:39-50
  Diederich, S., and A. Maisner
  
• (2008). Ephrin-B2 expression critically influences Nipah virus infection independent of its cytoplasmic tail. Virol. J. 5:165
  Thiel, L., Diederich, S., Erbar, S., Pfaff, D., Augustin, H. G., and A. Maisner
  
• (2008). Measles virus-induced block of transendothelial migration of T lymphocytes and infection-mediated virus spread across endothelial cell barriers. J. Virol. 82: 11273-11282
  Dittmar, S., Harms, H., Runkler, N., Maisner, A., Kim, K. S., and J. Schneider-Schaulies
  
• (2008). Role of endocylosis and cathepsin-mediated activation in Nipah virus entry. Virology 275: 391-400
  Diederich, S., Thiel, L., and A. Maisner
  
• (2008). Selective receptor expression restricts Nipah virus infection of endothelial cells. Virol. J. 5:142
  Erbar, S., Diederich, S., and A. Maisner
  
• (2009). "A small molecule inhibitor of Nipah virus envelope protein-mediated membrane fusion". J. Med. Chem. 52: 4257- 4265
  Niedermeier, S., Singethan, K., Rohrer, S.G., Matz, M., Kossner, M., Diederich, S., Maisnen A., Schmitz, J., Baumann, K., Holzgrabe, U., and J. Schneider-Schaulies
  
• (2009). "Nipah virus fusion protein: Influence of cleavage site mutations on the cleavability by cathepsin L, trypsin and furin". Virus Res. 2009 Aug 7. [Epub ahead of print]
  Diederich, S., Dietzel, E., and A. Maisner