Effects of chemokine signalling on microglial physiology: An electrophysiological and molecular biological approach

Antragsteller Professor Dr. Helmut Kettenmann
Fachliche Zuordnung Molekulare Biologie und Physiologie von Nerven- und Gliazellen
Förderung Förderung von 2002 bis 2006
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5378625
 

Projektergebnisse

Erstellungsjahr 2006

Zusammenfassung der Projektergebnisse

The research project has yielded several novel conclusions: 1) Our suggestion that CCL21 is involved in neuronal-microglial signalling has been confirmed both in vivo and in vitro. 2) CXCR3 is present and functional in human microglia, this finding shows the clinical relevance of the project. 3) The Groningen lab have recently shown that CCL21 in neurons is packed in vesicles and can be released, probably at nerve endings. This may be a good explanation for neurodegenerative/ neuroinflammatory processes at distance from a lesion. In total, it was a very successful collaboration and it is still going on.

DFG-Verfahren Sachbeihilfen
Internationaler Bezug Niederlande
Beteiligte Person Professor Dr. H.W.G.M. Boddeke