Effects of chemokine signalling on microglial physiology: An electrophysiological and molecular biological approach

Applicant Professor Dr. Helmut Kettenmann
Subject Area Molecular Biology and Physiology of Neurons and Glial Cells
Term from 2002 to 2006
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 5378625
 

Final Report

Final Report Year 2006

Final Report Abstract

The research project has yielded several novel conclusions: 1) Our suggestion that CCL21 is involved in neuronal-microglial signalling has been confirmed both in vivo and in vitro. 2) CXCR3 is present and functional in human microglia, this finding shows the clinical relevance of the project. 3) The Groningen lab have recently shown that CCL21 in neurons is packed in vesicles and can be released, probably at nerve endings. This may be a good explanation for neurodegenerative/ neuroinflammatory processes at distance from a lesion. In total, it was a very successful collaboration and it is still going on.

DFG Programme Research Grants
International Connection Netherlands
Participating Person Professor Dr. H.W.G.M. Boddeke