Chemoproteomic profiling of hydrolases that mediate microbial interactions (B10#)

• Subject Area: Microbial Ecology and Applied Microbiology ; Biochemistry ; Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology ; Metabolism, Biochemistry and Genetics of Microorganisms
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239748522

Non-ribosomal peptides are important chemical mediators and their hydrolytic transformation affects multipartite communities. In this project, we will develop and apply chemoproteomic methods to elucidate the prevalence, activity, and functional role of lipopeptide-modifying enzymes. As a result, we will gain a comprehensive understanding of bacterial hydrolytic transformations, identify novel bioactive compounds and uncover the molecular mechanisms of microbial interactions.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1127: Chemical Mediators in Complex Biosystems (ChemBioSys)
• Applicant Institution: Friedrich-Schiller-Universität Jena
• Project Head: Dr. Markus Lakemeyer