Bacterial evasion of selective autophagy pathways (F09*)

• Subject Area: Biochemistry ; Biophysics ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777

Pathogenic bacteria like Legionella pneumophila have evolved sophisticated mechanisms to hijack host cell autophagy to ensure bacterial survival and proliferation, notably through ubiquitination mechanisms. Building up on previous observations, this project will investigate how conventional and PR-ubiquitination control autophagy and mitochondrial homeostasis in infected cells and identify potential therapeutic targets to block the infection cycle of Legionella.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1177: Molecular and Functional Characterization of Selective Autophagy
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Ivan Dikic; Professor Dr. Volker Dötsch