Regulation of autophagy by microproteins and RNA modifications (F05*)

• Subject Area: Biochemistry ; General Genetics and Functional Genome Biology ; Cell Biology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 259130777

Our preliminary data revealed several microproteins that are significantly up- or downregulated upon autophagy disruption or infection with Acinetobacter baumannii. Building up on this observation, this project seeks to characterize the underlying molecular mechanisms that regulate the interplay between microproteins and autophagy and to assess the modulation of autophagy-related microproteins upon infection. One focus will be on tRNA modifications as key modulator of microprotein expression in the context of xenophagy.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1177: Molecular and Functional Characterization of Selective Autophagy
• Applicant Institution: Goethe-Universität Frankfurt am Main
• Project Heads: Professor Dr. Ivan Dikic; Professorin Dr. Stefanie Kaiser