GSC 270:  International Graduate School in Molecular Medicine Ulm

• Subject Area: Medicine
• Term: from 2007 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 53244728

• Final Report Year: 2019

Final Report Abstract

Ulm University founded the International Graduate School in Molecular Medicine Ulm (IGradU) in 2006 to provide high-quality postgraduate training. IGradU has been supported by the Excellence Initiative since 2007. The goal of IGradU was, and still is, to introduce doctoral candidates at Ulm University conducting research in the field of biomedicine to a structured postgraduate programme. Key research areas cover neurobiology, ageing & degeneration, oncology & endocrinology, virology, microbiology & biotechnology, systems biology, development & regeneration as well as trauma research and immune modulation. There are two structured training programmes on offer: the International PhD Programme in Molecular Medicine for doctoral candidates in natural sciences and the Experimental Medicine programme for doctoral candidates in medicine. As of 31 July 2019, 272 candidates have completed the PhD programme and 156 are enrolled. IGradU is run by a board, which in turn is advised by an international advisory committee. The International PhD Programme in Molecular Medicine offers a three-year structured doctorate including two intermediate evaluations. Admission regulations stipulate clear criteria for selection. During their postgraduate course, doctoral candidates are monitored by a Thesis Advisory Committee (TAC) made up of three supervisors. Graduates opt to receive either the international academic title of PhD or the German academic title Dr. rer. nat. In order to combat deficiencies in the supervision and quality of medical theses, the Medical Faculty implemented the structured training programme Experimental Medicine in 2005, which was subsequently adopted by IGradU in 2010. The Experimental Medicine programme is defined as a first step in the training of clinician scientists. The entry requirement for the programme is an above-average intermediate examination (part one of the national medical licensing exam). Doctoral candidates must interrupt their studies in medicine for nine months to concentrate fully on their experimental work. Doctoral candidates present their research in the programme's seminars and present up-to-date scientific literature in a Journal Club. A Junior Faculty was established during the second funding period. Young researchers who receive third-party funding for PhD students but are not yet allowed to be first supervisor due to the lack of a higher qualification (Habilitation) are organized within this group of scientists. Within IGradU, members of the Junior Faculty will be allowed to participate in TACs. Members of the Junior Faculty will be trained for their future career by providing additional training opportunities that concentrate on (i) academia; (ii) industry; or (iii) strengthening the training of clinician scientists. 2 Finally, IGradU served as a role model for the implementation of the Graduate & Professional Training Center Ulm (ProTrainU) that provides support for young scientist at the level of Ulm University.

Link to the final report

https://dx.doi.org/10.2314/KXP:1698163444

Publications

• Increased copper toxicity in Saccharomyces cerevisiae lacking VPS35, a component of the retromer and monogenic Parkinson disease gene in humans. Biochem Biophys Res Commun. 2016 Aug 5;476(4):528-533
  Sowada N, Stiller B, Kubisch C
  (See online at https://doi.org/10.1016/j.bbrc.2016.05.157)
• Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO J. 2011 Feb 2;30(3):569-81
  Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, Boeckers TM
  (See online at https://doi.org/10.1038/emboj.2010.336)
• Inferring Boolean network structure via correlation. Bioinformatics. 2011 Jun 1;27(11):1529-36
  Maucher M, Kracher B, Kühl M, Kestler HA
  (See online at https://doi.org/10.1093/bioinformatics/btr166)
• A boolean model of the cardiac gene regulatory network determining first and second heart field identity. PLoS One. 2012;7(10):e46798
  Herrmann F, Groß A, Zhou D, Kestler HA, Kühl M
  (See online at https://doi.org/10.1371/journal.pone.0046798)
• Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 2012 Apr 29;486(7402):256-60
  Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck St, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM
  (See online at https://doi.org/10.1038/nature11015)
• Multiscale binarization of gene expression data for reconstructing Boolean networks. IEEE/ACM Trans Comput Biol Bioinform. 2012;9(2):487-98
  Hopfensitz M, Mussel C, Wawra C, Maucher M, Kühl M, Neumann H, Kestler HA
  (See online at https://doi.org/10.1109/TCBB.2011.62)
• Peptide nanofibrils boost retroviral gene transfer and provide a rapid means for concentrating viruses. Nat Nanotechnol. 2013 Feb;8(2):130-6
  Yolamanova M, Meier C, Shaytan AK, Vas V, Bertoncini CW, Arnold F, Zirafi O, Usmani SM, Müller JA, Sauter D, Goffinet C, Palesch D, Walther P, Roan NR, Geiger H, Lunov O, Simmet T, Bohne J, Schrezenmeier H, Schwarz K, Ständker L, Forssmann WG, Salvatella X, Khalatur PG, Khokhlov AR, Knowles TP, Weil T, Kirchhoff F, Münch J
  (See online at https://doi.org/10.1038/NNANO.2012.248)
• The Wnt serpentine receptor Frizzled-9 regulates new bone formation in fracture healing. PLoS One. 2013 Dec 31;8(12):e84232
  Heilmann A, Schinke T, Bindl R, Wehner T, Rapp A, Haffner-Luntzer M, Nemitz C, Liedert A, Amling M, Ignatius A
  (See online at https://doi.org/10.1371/journal.pone.0084232)
• Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen. Nat Commun. 2014 Apr 1;5:3508
  Usmani SM, Zirafi O, Müller JA, Sandi-Monroy NL, Yadav JK, Meier C, Weil T, Roan NR, Greene WC, Walther P, Nilsson KP, Hammarström P, Wetzel R, Pilcher CD, Gagsteiger F, Fändrich M, Kirchhoff F, Münch J
  (See online at https://doi.org/10.1038/ncomms4508)
• Semen enhances HIV infectivity and impairs the antiviral efficacy of microbicides. Sci Transl Med. 2014 Nov 12;6(262):262ra157
  Zirafi O, Kim KA, Roan NR, Kluge SF, Müller JA, Jiang S, Mayer B, Greene WC, Kirchhoff F, Münch J
  (See online at https://doi.org/10.1126/scitranslmed.3009634)
• The chaperone Hsp90 and PPIases of the cyclophilin and FKBP families facilitate membrane translocation of Photorhabdus luminescens ADP-ribosyltransferases. Cell Microbiol. 2014 Apr;16(4):490-503
  Lang AE, Ernst K, Lee H, Papatheodorou P, Schwan C, Barth H, Aktories K
  (See online at https://doi.org/10.1111/cmi.12228)
• Unlabeling data can improve classification. Pattern Recognition Letters, 37:15–23, 2014
  Lausser L, Schmid F, Schmid M, Kestler HA
  (See online at https://doi.org/10.1016/j.patrec.2013.03.027)
• (2015): Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration. Journal of visualized experiments: JoVE, e52756
  Wehner D, Jahn C, and Weidinger G
  (See online at https://doi.org/10.3791/52756)
• A molecular tweezer antagonizes seminal amyloids and HIV infection. elife. 2015 Aug 18;4
  Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J
  (See online at https://doi.org/10.7554/eLife.05397.001)
• Haploinsufficiency of TBK1causes familial ALS and fronto-temporal dementia. Nat Neurosci. 2015 May;18(5):631-6
  Freischmidt A, Wieland T, Richter B, Ruf W, Schaeffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps S, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz S, Boeckers TM, Meyer T, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström T, Volk AE, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger T, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH
  (See online at https://doi.org/10.1038/nn.4000)
• Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells. Front Oncol. 2015 Nov 11;5:250
  Rall M, Kraft D, Volcic M, Cucu A, Nasonova E, Taucher-Scholz G, Bönig H, Wiesmüller L, Fournier C
  (See online at https://doi.org/10.3389/fonc.2015.00250)
• In vivo characterization of human myofibrillar myopathy genes in zebrafish. Biochem Biophys Res Commun. 2015 May 29;461(2):217-23
  Bührdel JB, Hirth S, Kessler M, Westphal S, Forster M, Manta L, Wiche G, Schoser B, Schessl J, Schröder R, Clemen CS, Eichinger L, Fürst DO, van der Ven PF, Rottbauer W, Just S
  (See online at https://doi.org/10.1016/j.bbrc.2015.03.149)
• Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):E1498-506
  Krabbe S, Duda J, Schiemann J, Poetschke C, Schneider G, Kandel ER, Liss B, Roeper J, Simpson EH
  (See online at https://doi.org/10.1073/pnas.1500450112)
• Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels. Retrovirology. 2015 Oct 9;12:86
  Heigele A, Joas S, Regensburger K, Kirchhoff F
  (See online at https://doi.org/10.1186/s12977-015-0213-1)
• Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish. Cell. 2015 Dec 3;163(6):1527-38
  Reichwald K, Petzold A, Koch P, Downie BR, Hartmann N, Pietsch S, Baumgart M, Chalopin D, Felder M, Bens M, Sahm A, Szafranski K, Taudien S, Groth M, Arisi I, Weise A, Bhatt SS, Sharma V, Kraus JM, Schmid F, Priebe S, Liehr T, Görlach M, Than ME, Hiller M, Kestler HA, Volff JN, Schartl M, Cellerino A, Englert C, Platzer M
  (See online at https://doi.org/10.1016/j.cell.2015.10.071)
• Neuronal expression of the transcription factor serum response factor modulates myelination in a mouse multiple sclerosis model. Glia. 2015 Jun;63(6):958-76
  Anastasiadou S, Liebenehm S, Sinske D, Meyer zu Reckendorf C, Moepps B, Nordheim A, Knöll B
  (See online at https://doi.org/10.1002/glia.22794)
• TDP-43 is intercellularly transmitted across axon terminals. J Cell Biol. 2015 Nov 23;211(4):897-911
  Feiler MS, Strobel B, Freischmidt A, Helferich AM, Kappel J, Brewer BM, Li D, Thal DR, Walther P, Ludolph AC, Danzer KM, Weishaupt JH
  (See online at https://doi.org/10.1083/jcb.201504057)
• Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes. Acta Neuropathol. 2016 Mar;131(3):379-91
  Bliederhaeuser C, Grozdanov V, Speidel A, Zondler L, Ruf WP, Bayer H, Kiechle M, Feiler MS, Freischmidt A, Brenner D, Witting A, Hengerer B, Fändrich M, Ludolph AC, Weishaupt JH, Gillardon F, Danzer KM
  (See online at https://doi.org/10.1007/s00401-015-1504-2)
• BiTrinA--multiscale binarization and trinarization with quality analysis. Bioinformatics. 2016 Feb 1;32(3):465-8
  Müssel C, Schmid F, Blätte TJ, Hopfensitz M, Lausser L, Kestler HA
  (See online at https://doi.org/10.1093/bioinformatics/btv591)
• Boolean modeling identifies Greatwall/MASTL as an important regulator in the AURKA network of neuroblastoma. Cancer Lett. 2016 Feb 1;371(1):79-89
  Dahlhaus M, Burkovski A, Hertwig F, Mussel C, Volland R, Fischer M, Debatin KM, Kestler HA, Beltinger C
  (See online at https://doi.org/10.1016/j.canlet.2015.11.025)
• DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci USA. 2016 Jul 26;113(30):E4311-9
  Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, Wiesmüller L
  (See online at https://doi.org/10.1073/pnas.1605828113)
• Exploring the induction of preproinsulin-specific Foxp3(+) CD4(+) Treg cells that inhibit CD8(+) T cell-mediated autoimmune diabetes by DNA vaccination. Sci Rep. 2016 Jul 11;6:29419
  Stifter K, Schuster C, Schlosser M, Boehm BO, Schirmbeck R
  (See online at https://doi.org/10.1038/srep29419)
• Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive. EBioMedicine. 2016 Oct;12:227-238
  Taudien S, Lausser L, Giamarellos-Bourboulis EJ, Sponholz C, Schöneweck F, Felder M, Schirra LR, Schmid F, Gogos C, Groth S, Petersen BS, Franke A, Lieb W, Huse K, Zipfel PF, Kurzai O, Moepps B, Gierschik P, Bauer M, Scherag A, Kestler HA, Platzer M
  (See online at https://doi.org/10.1016/j.ebiom.2016.08.037)
• GiANT: gene set uncertainty in enrichment analysis. Bioinformatics. 2016 Jun 15;32(12):1891-4
  Schmid F, Schmid M, Müssel C, Sträng JE, Buske C, Bullinger L, Kraus JM, Kestler HA
  (See online at https://doi.org/10.1093/bioinformatics/btw030)
• GPR56 contributes to the development of acute myeloid leukemia in mice. Leukemia. 2016 Aug;30(8):1734-41
  Daria D, Kirsten N, Muranyi A, Mulaw M, Ihme S, Kechter A, Hollnagel M, Bullinger L, Döhner K, Döhner H, Feuring-Buske M, Buske C
  (See online at https://doi.org/10.1038/leu.2016.76)
• Guanylate Binding Protein (GBP) 5 Is an Interferon-Inducible Inhibitor of HIV-1 Infectivity. Cell Host Microbe. 2016 Apr 13;19(4):504-14
  Krapp C, Hotter D, Gawanbacht A, McLaren PJ, Kluge SF, Stürzel CM, Mack K, Reith E, Engelhart S, Ciuffi A, Hornung V, Sauter D, Telenti A, Kirchhoff F
  (See online at https://doi.org/10.1016/j.chom.2016.02.019)
• Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS One. 2016 Mar 8;11(3):e0150323
  Hirth S, Bühler A, Bührdel JB, Rudeck S, Dahme T, Rottbauer W, Just S
  (See online at https://doi.org/10.1371/journal.pone.0150323)
• Thioredoxin reductase inhibitor auranofin prevents membrane transport of diphtheria toxin into the cytosol and protects human cells from intoxication. Toxicon. 2016 Jun 15;116:23-8
  Schnell L, Dmochewitz-Kück L, Feigl P, Montecucco C, Barth H
  (See online at https://doi.org/10.1016/j.toxicon.2015.04.012)
• Validation of a multiplexing technique to determine the intrathecal, polyspecific antiviral immune response in multiple sclerosis. Expert Rev Mol Diagn. 2016 Dec;16(12):1353-1356
  Huss A, Buttmann M, Brecht I, Weishaupt A, Otto M, Tumani H
  (See online at https://doi.org/10.1080/14737159.2016.1249468)
• A model of the onset of the senescence associated secretory phenotype after DNA damage induced senescence. PLoS Comput Biol. 2017 Dec 4;13(12):e1005741
  Meyer P, Maity P, Burkovski A, Schwab J, Müssel C, Singh K, Ferreira FF, Krug L, Maier HJ, Wlaschek M, Wirth T, Kestler HA, Scharffetter-Kochanek K
  (See online at https://doi.org/10.1371/journal.pcbi.1005741)
• An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation. Development. 2017 Jan 15;144(2):321-333
  Rothe M, Kanwal N, Dietmann P, Seigfried FA, Hempel A, Schütz D, Reim D, Engels R, Linnemann A, Schmeisser MJ, Bockmann J, Kühl M, Boeckers TM, Kühl SJ
  (See online at https://doi.org/10.1242/dev.147462)
• Comparison of Sirtuin 3 Levels in ALS and Huntington's Disease-Differential Effects in Human Tissue Samples vs. Transgenic Mouse Models. Front Mol Neurosci. 2017 May 26;10:156
  Buck E, Bayer H, Lindenberg KS, Hanselmann J, Pasquarelli N, Ludolph AC, Weydt P, Witting A
  (See online at https://doi.org/10.3389/fnmol.2017.00156)
• Complement C5a-Induced Changes in NeutrophilMorphology During Inflammation. Scand J Immunol. 2017 Sep;86(3):143-155
  Denk S, Taylor RP, Wiegner R, Cook EM, Lindorfer MA, Pfeiffer K, Paschke S, Eiseler T, Weiss M, Barth E, Lambris JD, Kalbitz M, Martin T, Barth H, MessererDAC, Gebhard F, Huber- Lang MS
  (See online at https://doi.org/10.1111/sji.12580)
• Epithelial NEMO/IKKγ limits fibrosis and promotes regeneration during pancreatitis. Gut. 2017 Nov;66(11):1995-2007
  Chan LK, Gerstenlauer M, Konukiewitz B, Steiger K, Weichert W, Wirth T, Maier HJ
  (See online at https://doi.org/10.1136/gutjnl-2015-311028)
• Frizzled 3 acts upstream of Alcam during embryonic eye development. Dev Biol. 2017 Jun 1;426(1):69-83
  Seigfried FA, Cizelsky W, Pfister AS, Dietmann P, Walther P, Kühl M, Kühl SJ
  (See online at https://doi.org/10.1016/j.ydbio.2017.04.004)
• Generic wound signals initiate regeneration in missingtissue contexts. Nat Commun. 2017 Dec 22;8(1):2282
  Owlarn S, Klenner F, Schmidt D, Rabert F, Tomasso A, Reuter H, Mulaw MA, Moritz S, Gentile L, Weidinger G, Bartscherer K
  (See online at https://doi.org/10.1038/s41467-017-02338-x)
• Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation. Leukemia. 2017 Nov;31(11):2491-2502
  Thiel VN, Giaimo BD, Schwarz P, Soller K, Vas V, Bartkuhn M, Blätte TJ, Döhner K, Bullinger L, Borggrefe T, Geiger H, Oswald F
  (See online at https://doi.org/10.1038/leu.2017.105)
• Hsp70 facilitates trans-membrane transport of bacterial ADP-ribosylating toxins into the cytosol of mammalian cells. Sci Rep. 2017 Jun 2;7(1):2724
  Ernst K, Schmid J, Beck M, Hägele M, Hohwieler M, Hauff P, Ückert AK, Anastasia A, Fauler M, Jank T, Aktories K, Popoff MR, Schiene-Fischer C, Kleger A, Müller M, Frick M, Barth H
  (See online at https://doi.org/10.1038/s41598-017-02882-y)
• Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing. PLoS One. 2017 Jun 14;12(6):e0179512
  Bergdolt S, Kovtun A, Hägele Y, Liedert A, Schinke T, Amling M, Huber-Lang M, Ignatius A
  (See online at https://doi.org/10.1371/journal.pone.0179512)
• Osteopontin attenuates aging-associated phenotypes of hematopoietic stem cells. EMBO J. 2017 Apr 3;36(7):840-853. Erratum in: EMBO J. 2017 May 15;36(10):1463
  Guidi N, Sacma M, Ständker L, Soller K, Marka G, Eiwen K, Weiss JM, Kirchhoff F, Weil T, Cancelas JA, Florian MC, Geiger H
  (See online at https://doi.org/10.15252/embj.201694969)
• Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation. PLoS Pathog. 2017 Aug 31;13(8):e1006598
  Hotter D, Krabbe T, Reith E, Gawanbacht A, Rahm N, Ayouba A, Van Driessche B, Van Lint C, Peeters M, Kirchhoff F, Sauter D
  (See online at https://doi.org/10.1371/journal.ppat.1006598)
• Semen amyloids participate in spermatozoa selection and clearance. elife. 2017 Jun 27;6
  Roan NR, Sandi-Monroy N, Kohgadai N, Usmani SM, Hamil KG, Neidleman J, Montano M, Ständker L, Röcker A, Cavrois M, Rosen J, Marson K, Smith JF, Pilcher CD, Gagsteiger F, Sakk O, O'Rand M, Lishko PV, Kirchhoff F, Münch J, Greene WC
  (See online at https://doi.org/10.7554/eLife.24888.001)
• Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells. Exp Hematol. 2017 Nov;55:45-55
  Senger K, Marka G, Soller K, Sakk V, Florian MC, Geiger H
  (See online at https://doi.org/10.1016/j.exphem.2017.07.005)
• Stability of Signaling Pathways during Aging-A Boolean Network Approach. Biology (Basel). 2017 Dec 18;6(4)
  Schwab JD, Siegle L, Kühlwein SD, Kühl M, Kestler HA
  (See online at https://doi.org/10.3390/biology6040046)
• The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells. Sci Rep. 2017 Apr 4;7(1):613
  Schuster M, Schnell L, Feigl P, Birkhofer C, Mohr K, Roeder M, Carle S, Langer S, Tippel F, Buchner J, Fischer G, Hausch F, Frick M, Schwan C, Aktories K, Schiene-Fischer C, Barth H
  (See online at https://doi.org/10.1038/s41598-017-00780-x)
• The inflammatory phase of fracture healing is influenced by oestrogen status in mice. Eur J Med Res. 2017 Jul 6;22(1):23
  Haffner-Luntzer M, Fischer V, Prystaz K, Liedert A, Ignatius A
  (See online at https://doi.org/10.1186/s40001-017-0264-y)
• ViSiBooL-visualization and simulation of Boolean networks with temporal constraints. Bioinformatics. 2017 Feb 15;33(4):601-604
  Schwab J, Burkovski A, Siegle L, Müssel C, Kestler HA
  (See online at https://doi.org/10.1093/bioinformatics/btw661)
• Aged murine hematopoietic stem cells drive aging-associated immune remodeling. Blood. 2018 Aug 9;132(6):565-576
  Leins H, Mulaw M, Eiwen K, Sakk V, Liang Y, Denkinger M, Geiger H, Schirmbeck R
  (See online at https://doi.org/10.1182/blood-2018-02-831065)
• Automatic Screening for Perturbations in Boolean Networks. Front Physiol. 2018 Apr 24;9:431
  Schwab JD, Kestler HA
  (See online at https://doi.org/10.3389/fphys.2018.00431)
• Base excision repair proteins couple activationinduced cytidine deaminase and endonuclease G during replication stress-induced MLL destabilization. Leukemia. 2018 Jan;32(1):159-167
  Gole B, Mian E, Rall M, Wiesmüller L
  (See online at https://doi.org/10.1038/leu.2017.191)
• Coincidence of lymphomatoid granulomatosis, chronic myelomonocytic leukemia, and anaplastic T cell lymphoma after methotrexate therapy for rheumatoid arthritis. Ann Hematol. 2019 Feb;98(2):515-517
  Dugge R, Kreipe H, Rosenwald A, Lehmann U, Möller P, Barth TFE, Erlemann R
  (See online at https://doi.org/10.1007/s00277-018-3434-2)
• Comparison of Fatty Acid and Gene Profiles in Skeletal Muscle in Normal and Obese C57BL/6J Mice before and after Blunt Muscle Injury. Front Physiol. 2018 Jan 30;9:19
  Werner JU, Tödter K, Xu P, Lockhart L, Jähnert M, Gottmann P, Schürmann A, Scheja L, Wabitsch M, Knippschild U
  (See online at https://doi.org/10.3389/fphys.2018.00019)
• Distinct Effects of IL-6 Classic and Trans- Signaling in Bone Fracture Healing. Am J Pathol. 2018 Feb;188(2):474-490
  Prystaz K, Kaiser K, Kovtun A, Haffner-Luntzer M, Fischer V, Rapp AE, Liedert A, Strauss G, Waetzig GH, Rose-John S, Ignatius A
  (See online at https://doi.org/10.1016/j.ajpath.2017.10.011)
• Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia. J Clin Oncol. 2018 Apr 1;36(10):1007-1016
  Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, Döhner K, Mätzig T, Ng M, Reinhardt D, Döhner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F, Klusmann JH
  (See online at https://doi.org/10.1200/JCO.2017.75.2204)
• FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL. Blood. 2019 Feb 21;133(8):830-839
  Close V, Close W, Kugler SJ, Reichenzeller M, Yosifov DY, Bloehdorn J, Pan L, Tausch E, Westhoff MA, Döhner H, Stilgenbauer S, Oswald F, Mertens D
  (See online at https://doi.org/10.1182/blood-2018-09-874529)
• Fine-tuning of FOXO3A in cHL as a survival mechanism and a hallmark of abortive plasma cell differentiation. Blood. 2018 Apr 5;131(14):1556-1567
  Osswald CD, Xie L, Guan H, Herrmann F, Pick SM, Vogel MJ, Gehringer F, Chan FC, Steidl C, Wirth T, Ushmorov A
  (See online at https://doi.org/10.1182/blood-2017-07-795278)
• Human Serum Albumin Is an Essential Component of the Host Defense Mechanism Against Clostridium difficile Intoxication. J Infect Dis. 2018 Sep 22;218(9):1424-1435
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