The role of a previously unrecognised E3 ligase in regulating TLR3 signalling (A12*)

• Subject Area: Cell Biology ; Immunology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 414786233

The Walczak group recently found that upon TLR3 stimulation, different from TNFR1 signalling and despite LUBAC also forming part of the TLR3 signaling complex, TBK1 activation is independent from LUBAC. Parting therefrom, another E3 ligase was now identified as required for TBK1 activation following TLR3 stimulation. During the next funding period, the role of this enzyme in the regulation of TLR3 signaling will be characterized in vitro and in vivo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1403: Cell Death in Immunity, Inflammation and Disease
• Applicant Institution: Universität zu Köln
• Project Head: Professor Henning Walczak, Ph.D.