Regulation of organic cation-transporters

• Applicant: Professor Dr. Eberhard Schlatter
• Subject Area: Nephrology
• Term: from 2001 to 2008
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5306942

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• Characterization of regulatory mechanisms and states of human organic cation transporter 2. Am. J. Physiol. Cell Physiol., 290(6):C1521-1531, 2006
  Biermann J, Lang D, Gorboulev V, Koepsell H, Sindic A, Schröter R, Zvirbliene A, Pavenstädt H, Schlatter E, Ciarimboli G
  
• Mechanisms of Ca2+/calmodulin-regulation of hOCT2. Acta Physiol. 2006,186:
  Biermann J, Lang D, Gorboulev V, Zvirbliene A, Koepsell H, Schlatter E, Ciarimboli G
  
• Mutationen der Aminosäuren C322 und C451 heben die PKC-Regulation des organischen Kationentransporters der Ratte (rOCT1) auf ohne die apparenten Substrataffinitäten zu beeinflussen. Nieren-Hochdruckkrankheiten. 2006
  Grummich O, Koepsell H, Schlatter E, Ciarimboli G
  
• Role of hOCT2 in drug-induced nephrotoxicity. Acta Physiol. 2006,186:
  Ciarimboli G, Vollenbröker B, Koepsell H, Schlatter E
  
• Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451 ) and rOCT2 (C451) critical for transport activity and substrate affinity. Am. J. Physiol. Renal Physiol., 293(3):F767-79, 2007
  Sturm A, Gorboulev V, Gorbunov D, Keller T, Volk C, Schmitt BM, Schlachtbauer P, Ciarimboli G, Koepsell H
  
• Oligomerization of hOCT2 studied with the split-ubiquitin membrane yeast two-hybrid technique. Acta Physiol. 2007, 189(S653):55
  Brast S, Schlatter E, Grafen C, Ciarimboli G
  
• (2008) Characterization of regulatory pathways of rat organic cation transporter 2 (rOCT2). Acta Physiol. 2008,192(S663):53
  Ciarimboli G, Wilde S, Neugebauer U, Koepsell H, Schlatter E
  
• (2008) Specific uptake of ifosfamide by organic cation transporter hOCT2 explains ifosfamide-associated renal Fanconi syndrome
  Ciarimboli G, Vollenbröker B, Hagos Y, Reuter S, Burckhardt G, Pavenstädt H, Rossi R, Schlatter E, Kleta R
  
• Importance of oligomerization for the human organic cation transporter 2 (hOCT2). Acta Physiol. 2008,192(S663):59
  Brast S, Schlatter E, Pavenstädt H, Ciarimboli G
  
• Organic cation transporters. Xenobiotica, 38:7,936-971, 2008
  Ciarimboli G.
  
• Regulation of human organic cation transporter 3 (hOCT3) by new interacting partners. FASEB J, 2008,22:935.17
  Ciarimboli G, Albiker C, Brast S, Humberg J, Schlatter E
  
• The human organic cation transporter 2 (hOCT2) transports cadmium (Cd2+) and mediates Cd2+ induced cell death. Acta Physiol. 2008,192(S663):135
  Thévenod F, Ciarimboli G, Wolff NA, Schlatter E, Koepsell H
  
• The human organic cation transporter 2 (hOCT2) transports cadmium (Cd2+) and mediates Cd2+induced cell death. FASEBJ, 2008,22:1202.6
  Thévenod F, Ciarimboli G, Wolff NA, Schlatter E, Koepsell H