Role of type I interferon in inflammatory bone disease (C06)

• Subject Area: Immunology ; Human Genetics ; Pediatric and Adolescent Medicine ; Rheumatology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

Project C06 will analyze how unabated type I IFN drives inflammatory bone loss. Primary fibroblasts from patients with IFIH1 mutations secrete large amounts of VEGF, a major regulator of bone, suggesting a previously unappreciated link between type I IFN and VEGF in bone homeostasis. The aim of this project is to gain mechanistic insight into type I IFN-mediated inflammatory bone disease and to pinpoint novel pathways that can be targeted for therapeutic intervention.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professorin Dr. Min Ae Lee-Kirsch; Professor Dr. Georg Schett