Role of type I interferon in inflammatory bone disease (C06)

Subject Area Immunology
Human Genetics
Pediatric and Adolescent Medicine
Rheumatology
Term since 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319
 

Project Description

Project C06 will analyze how unabated type I IFN drives inflammatory bone loss. Primary fibroblasts from patients with IFIH1 mutations secrete large amounts of VEGF, a major regulator of bone, suggesting a previously unappreciated link between type I IFN and VEGF in bone homeostasis. The aim of this project is to gain mechanistic insight into type I IFN-mediated inflammatory bone disease and to pinpoint novel pathways that can be targeted for therapeutic intervention.
DFG Programme CRC/Transregios
Subproject of TRR 369:  DIONE Degeneration of bone induced by inflammation
Applicant Institution Friedrich-Alexander-Universität Erlangen-Nürnberg
Project Heads Professorin Dr. Min Ae Lee-Kirsch; Professor Dr. Georg Schett