Role of type I interferon in inflammatory bone disease
(C06)
Subject Area
Immunology
Human Genetics
Pediatric and Adolescent Medicine
Rheumatology
Term
since 2024
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319
Project C06 will analyze how unabated type I IFN drives inflammatory bone loss. Primary fibroblasts from patients with IFIH1 mutations secrete large amounts of VEGF, a major regulator of bone, suggesting a previously unappreciated link between type I IFN and VEGF in bone homeostasis. The aim of this project is to gain mechanistic insight into type I IFN-mediated inflammatory bone disease and to pinpoint novel pathways that can be targeted for therapeutic intervention.
DFG Programme
CRC/Transregios
