Innate immune training-mediated regulation of osteoclasts and inflammatory bone loss (C03)

Subject Area Toxicology, Laboratory Medicine
Term since 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319
 

Project Description

Project C03 will analyze whether trained immunity may also affect osteoclast generation and function and how this might contribute to inflammatory bone loss. The overarching theme and long-term perspective of C03 is to show that diseases related to inflammatory bone loss are associated with "trained" bone-marrow progenitors, poised towards enhanced osteoclastogenesis and hence identify trained immunity-associated therapeutic targets.
DFG Programme CRC/Transregios
Subproject of TRR 369:  DIONE Degeneration of bone induced by inflammation
Applicant Institution Friedrich-Alexander-Universität Erlangen-Nürnberg
Project Heads Professor Dr. Triantafyllos Chavakis; Professorin Dr. Lydia Kalafati