Role for the c-type lectin receptor Dectin-1 (Clec7a) in inflammatory bone disease (C02)

• Subject Area: Dentistry, Oral Surgery ; Immunology ; Rheumatology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

Project C02 will delineate how Dectin-1 links infection to bone destruction using periodontitis as a prototype disease, in which chronic infection leads to bone loss. Overall, the project seeks to define a novel pathway that orchestrates bone destruction in the oral cavity with the long-term aim to identify risk populations of periodontitis patients that would profit from early anti-resorptive treatment.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Dr. Bettina Grötsch; Professor Dr. Manuel Weber