The role of the iron regulator transferrin receptor 2 in infection and bone (A05)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501752319

The project A05 will delineate how iron and the iron regulator Tfr2 triggers inflammation induced bone loss by governing osteoclastogenesis and their mitochondrial metabolism. An iron overload murine model based on mutated iron-regulating transferrin receptor 2 will be used to identify how iron and iron regulators governs osteoclast function and metabolism during inflammatory bone diseases, such as arthritis and periodontitis. These insights will pave the way to further uncover effects of iron and additional iron regulators on inflammatory bone changes and exploit iron-dependent metabolites for therapeutic purposes.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 369: DIONE Degeneration of bone induced by inflammation
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Dr. Ulrike Baschant; Dr. Carina Scholtysek