Metabolic control of corneal hem- and (lymph)angiogenesis (A04)

• Subject Area: Ophthalmology
• Term: since 2024
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 501530074

Metabolic control of corneal hem- and (lymph)angiogenesis represents the central objective of this project. Our own recent findings show that a dynamic metabolic switch by involving mitochondrial oxidative phosphorylation (OxPhos) within vasculature guarantees cellular growth under energetically demanding angiogenic processes. Here we aim to explore the mitochondrial control of pathological hem- and lymphangiogenesis in the cornea and furthermore to investigate the therapeutic value of mitochondria in neovascular eye diseases.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1607: Towards immunomodulatory and anti(lymph)angiogenic therapies for age-related blinding eye diseases
• Applicant Institution: Universität zu Köln
• Project Heads: Dr. Karina Hadrian; Professor Dr. Hamid Kashkar