Role of microglia-interneuron interactions in shaping network function (B06)

Subject Area Cognitive, Systems and Behavioural Neurobiology
Term since 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 514483642
 

Project Description

In this project, we aim to explore the role of bidirectional communication between microglia and parvalbumin-positive interneurons (PVIs) in the hippocampal CA1 region. We will test the hypothesis that microglial regulation of PVI activity modulates gamma frequency oscillations that critically depend on PVI function. This will be tested in wild-type and DISC1 mice, which serve as a model system of impaired PVI and gamma function. Using a combination of in vivo and ex vivo electrophysiology, multi-photon imaging and biochemical analyses, we aim to identify the impact of microglia-PVI interactions for microcircuit function and to reveal how microglial dysfunction relates to oscillatory network defects.
DFG Programme CRC/Transregios
Subproject of TRR 384:  Inhibitory neurons: shaping the cortical code (IN-CODE)
Applicant Institution Albert-Ludwigs-Universität Freiburg
Project Heads Professor Dr. Christian Madry; Dr. Jonas-Frederic Sauer