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Complementary inhibitory control of dendritic top-down information processing in auditory cortex (A07)

Subject Area Cognitive, Systems and Behavioural Neurobiology
Term since 2024
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 514483642
 
The distal apical dendrites of pyramidal neurons in neocortical layer 1 receive internally-generated top-down information which is vital for many higher brain functions, but how dendritic encoding of these signals is controlled by local inhibition is incompletely understood. Here, we combine spatially-resolved optogenetics, in vivo 2-photon calcium imaging, chemogenetics and cortex-dependent conditioning to dissect the contribution of two distinct types of GABAergic interneurons in these processes. Based on published and our preliminary evidence, we hypothesize a complementary division of labor between the two interneuron types in terms of circuit organization, interconnectivity and in vivo function.
DFG Programme CRC/Transregios
Major Instrumentation Polygon 1000
Instrumentation Group 5770 Lichtmodulatoren, Elektrooptik, Magnetooptik
Applicant Institution Albert-Ludwigs-Universität Freiburg
 
 

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