Pharmakokinetik, Pharmakodynamik und klinische Anwendbarkeit von neuen Somatostatin-Analoga zur Endoradiotherapie bei neuroendokrinen Tumoren im Tiermodell

• Applicant: Professor Dr. Matthias Max Weber, since 3/2007
• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: from 2000 to 2006
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5282748

• Final Report Year: 2007

Final Report Abstract

No abstract available

Publications

• Pre-therapeutic dosimetry and biodistribution of 86Y-DOTA-Phel-Tyr3-octreotide versus 111In-pentetreotide in patients with advanced neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2004 Oct;31(10):1386-92
  Helisch A, Forster GJ, Reber H, Buchholz HG, Arnold R, Goke B, Weber MM, Wiedenmann B, Pauwels S, Haus U, Bouterfa H, Bartenstein P
  
• (2005). In vivo-Diagnostik von Somatostatinrezeptoren mittels konfokaler Laserendomikroskopie. Z Gastroenterol, 43(Suppl. 1):1031
  C. Fottner, E. Schirrmacher, M. Goetz, P. Feilen, P. Bartenstein, P.R. Galle, M.F. Neurath, M.M. Weber, R. Kiesslich
  
• (2005). Peptidrezeptorvermittelte Radionuklidtherapie fortgeschrittener neuroendokriner Tumore mit 90Y-DOTATOC - Klinische Ergebnisse. Z Gastroenterol. 43(Suppl. 1):1031
  C. Fottner, A. Helisch, T. Minnemann, M. Zschommler, P. R. Galle, P. Bartenstein, M.M. Weber
  
• In vitro and in vivo evaluation of novel glibenclamide derivatives as imaging agents for the non-invasive assessment of the pancreatic islet cell mass in animals and humans. Exp Clin Endocrinol Diabetes. 2005 Jul;113(7):388-95
  Schneider S, Feilen PJ, Schreckenberger M, Schwanstecher M, Schwanstecher C, Buchholz HG, Thews O, Oberholzer K, Korobeynikov A, Bauman A, Comagic S, Piel M, Schirrmacher E, Shiue CY, Alavi AA, Bartenstein P, Rösch F, Weber MM, Klein HH, Schirrmacher R
  
• Visualisation of a somatostatin receptor-expressing tumour with Ga-DOTATOC SPECT. Eur J Nucl Med Mol Imaging. 2005 Sep;32(9): 1129
  Zhernosekov K, Aschoff P, Filosofov D, Jahn M, Jennewein M, Adrian HJ, Bihl H, Rösch F
  
• In vivo-molecular and morphological imaging of somatostatin receptors by confocal real time laser mini-microscopy (2006). Experimental and Clinical Endocrinology & Diabetes 114 (Suppl.1):7
  C. Fottner, E. Schirrmacher, M. Goetz, P. Feilen, P. Bartenstein, P.R. Galle, M.F. Neurath, M.M. Weber, R. Kiesslich
  
• Targeted peptide receptor radionuclide therapy for advanced neuroendocrine tumors (NET) with 90Y-DOTATOC - tumor response and clinical benefit (2006). Experimental and Clinical Endocrinology & Diabetes 114 (Suppl.1): 36
  C. Fottner, A. Helisch, T. Minnemann, M. Zschommler, P. R. Galle, P. Bartenstein, M.M. Weber
  
• (2007) In vivo confocal real-time mini-j microscopy in animal models of human inflammatory and neoplastic diseases. Endoscopy 39: 350-356
  Goetz M., Fottner C., Schirmacher E., Delaney P., Gregor S., Schneider C., Strand D., Kanzler S., Memadathil B., Weyand E., Holtmann M., Schirrmacher R., Weber MM, Anlauf M., Klöppl G., Vieth M., Galle PR., Bartenstein P., Neurath MF., Kiesslich R.