Decision between local mitophagy and neuronal cell death (A09)

Subject Area Cell Biology
Term since 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 471011418
 

Project Description

Recent advances in cell death research provide insight that cellular signaling can be spatially restricted. The enormous size of neurons and the length of axons generates particular challenges for the subcellular regulation of mitochondrial apoptosis processes. This project will investigate how co-transportation of PINK1 mRNA in a synaptojanin 2-binding protein-dependent manner on axonal mitochondria contributes to mitochondrial resilience, mitophagy of damaged mitochondria, caspase activation and subcellular neurite death decisions.
DFG Programme CRC/Transregios
Subproject of TRR 353:  Regulation of cell death decisions
Applicant Institution Universität Konstanz
Project Head Professorin Dr. Angelika Harbauer