From cross-tissue multi-omics toward brain-region-specific mechanisms within the addiction neurocircuitry: a translational approach
(B10*)
Subject Area
Experimental Models for the Understanding of Nervous System Diseases
Biological Psychiatry
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 402170461
We will apply a translational multi-omics approach to identify genes and pathways associated with cocaine use disorder (CUD) for functional validation in animal models. For target identification, we will integrate bulk- and sn-multiome data on CUD in humans with snRNAseq data derived from corresponding brain regions from a well-established animal model of cocaine addiction, thus providing synergistic cross-species gene discovery. These gene targets will be functionally validated in rodent brain via virus-mediated gene delivery in a brain region/cell-specific manner, and gene expression changes will be evaluated on addicted-like phenotypes in the rat model.
DFG Programme
CRC/Transregios
