Transcriptomics and epigenetic data analysis (S02*)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 397484323

The bioinformatics platform will support the research projects of the consortium in planning of experimental setups, analysis, manuscript preparation and publication of next-generation sequencing (NGS) data. Multiple projects have already or will generate bulk and/or single-cell sequencing datasets of mRNA, epigenetic changes in histone modifications as well as accessible chromatin regions (ATAC sequencing), which will be analysed by the researchers of the bioinformatics platform. Using a diverse set of statistical tools and machine learning algorithms, the platform will also perform analysis of CRISPR-based functional screens and data mining by integration of clinical, proteomics and sequencing data to develop novel data-driven research approaches.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 259: Aortic Disease
• Applicant Institution: Rheinische Friedrich-Wilhelms-Universität Bonn
• Project Heads: Dr. Maximilian Billmann, since 7/2023; Dr. Susanne Schmidt, since 7/2023