GUARD – Genes Underlying AoRtic valve Disease (C05 [B07])

Subject Area Cardiology, Angiology
Human Genetics
Term since 2023
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 397484323
 

Project Description

Aortic valve stenosis (AS) develops in the context of a bi- or tricuspid aortic valve formation. Genetic factors are involved in the development of both AS types. However, the genetic architecture is heterogeneous and depends on the effect size and frequency of the underlying disease variants/mutations. Through our scientific network GUARD (www.guard-net.de), we carried out two large genome-wide association studies (GWAS) that led to the identification of common risk variants for the development of both AS types. We now aim to identify the entire spectrum of genetic risk factors for bi- and tricuspid AS and to analyse them together with other disease-relevant data sets using modern systems biology approaches
DFG Programme CRC/Transregios
Subproject of TRR 259:  Aortic Disease
Applicant Institution Rheinische Friedrich-Wilhelms-Universität Bonn
Project Heads Dr. Baravan Al-Kassou, since 7/2023; Dr. Maximilian Billmann, since 7/2023; Professor Dr. Markus M. Nöthen, since 7/2023