The role of chromosome topology in MYCN function and neuroblastoma evolution and its potential for clinical exploitation
(B01)
Subject Area
Cell Biology
Hematology, Oncology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 493872418
The project aims to test the dependence of MYCN-amplified NB growth and evolutionary chemoresistance on the function of TFIIIC and the exosome complex. To this end, TFIIIC is knocked down by shRNA in a transgenic mouse model and the structural subunit of the exosome complex, EXOSC5, is decimated by an auxin-inducible degron in an orthotopic mouse transplantation model. The TFIIIC/AURKA balance is also disrupted by PROTAC-mediated AURKA degradation. This is a first step towards clinical use for the treatment of patients with relapsed MYCN-amplified NB.
DFG Programme
Collaborative Research Centres
