Targeted phosphoproteomics-based prediction of drug responses to combinatorial treatment
(A07)
Subject Area
Bioinformatics and Theoretical Biology
Biochemistry
Hematology, Oncology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 493872418
This project aims to improve analytical methods to detect states in signaling networks that could predict drug sensitivity. A targeted phosphoproteome (PP) panel for the NB will be designed, and comprehensive catalogs of on- and off-target effects for drugs used in perturbation studies will be generated. A computerized tool will be developed to convert PP profiles into easily interpretable metabolic pathway activity values, and then applied to a representative cell line panel. Computer models will be used to hypothesize resistance mechanisms and synergies for combinatorial treatments.
DFG Programme
Collaborative Research Centres
