The role of epigenetic modifications in neuroblastoma evolution and plasticity (A05)

• Subject Area: General Genetics and Functional Genome Biology ; Bioinformatics and Theoretical Biology ; Developmental Biology ; Pediatric and Adolescent Medicine
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 493872418

The project aims to investigate the relationships between genetic and epigenetic influences in tumor evolution through bulk and single-cell sequencing studies of genomic and epigenomic profiles in spatially separated tumor tissue samples. Computational tools will be developed to analyze epigenetic trait responses to chemotherapeutic pressure and elucidate resistance mechanisms to epigenetically targeted drugs. The goal is to identify and validate biomarkers for clinical disease progression.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1588: Decoding and Targeting Mechanisms of Neuroblastoma Evolution
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Dr. Altuna Akalin; Privatdozent Dr. Frank Westermann