Spatial organization and function of RNA in primary neuroblastomas and their TME (A04)

• Subject Area: Hematology, Oncology ; Bioinformatics and Theoretical Biology ; Pediatric and Adolescent Medicine ; Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 493872418

This project will use spatially resolved single cell transcriptomics to map the cellular and molecular composition of primary neuroblastoma and assess the impact of cellular organization on treatment resistance and metastasis. The project is expected to yield novel predictive biomarkers and therapeutic approaches that target newly identified targets and act on mechanisms of resistance and metastasis. Steps will be taken to exploit the new findings diagnostically and therapeutically.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1588: Decoding and Targeting Mechanisms of Neuroblastoma Evolution
• Applicant Institution: shared FU Berlin and HU Berlin through:; Charité - Universitätsmedizin Berlin
• Project Heads: Professorin Dr. Angelika Eggert; Professor Dr. Nikolaus Rajewsky