Amoeboid migration in the presence of multiple centrosomes

• Applicant: Professorin Dr. Eva Kiermaier
• Subject Area: Cell Biology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 524747443

Cell migration is crucially important for numerous physiological and pathological processes. White blood cells (leukocytes) are among the fastest cells moving in our body. Their highly motile behavior essentially contributes to the efficient induction of the immune response. The molecules that regulate most cellular functions related to cell migration belong to a complex network referred to as the cytoskeleton. While various principles of actin-related processes in cellular locomotion are about to be revealed, much less is known about the role of microtubule arrays and microtubule organizing centers during amoeboid cell migration. In contrast to other highly specialized cell types, leukocytes mainly employ centrosomes for microtubule nucleation, which amplify upon immune activation. This research proposal aims to decipher how multiple centrosomes are organized during leukocyte migration in environments of different complexities and how they contribute to enhanced directional locomotion along gradients of chemotactic cues. Knowledge gained from this research proposal will lead to novel insights into leukocyte navigation strategies with the potential to aid in the development of new treatment options against autoimmune diseases and cancer.

• DFG Programme: Research Grants