Mechanism and dynamics of the nuclear localization of the human 26S proteasome (B11*)

• Subject Area: Structural Biology
• Term: Funded in 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403222702

The proteasome is a large molecular machinery for degradation of proteins. It is localized in the cytosol, but also in the nucleus. The mechanisms that facilitate and regulate nuclear import are poorly understood. We found that Akirin2 dynamically associates with the proteasome during import. By using structural and biophysical approaches we aim to characterize nuclear import complexes and dissect the underlying mechanisms in transport of large cargo.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1381: Dynamic organization of cellular protein machineries: From biogenesis and modular assembly to function
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. David Haselbach