Elucidating microbiota-dependent and independent functions of inflammasome-mediated innate immunity during hepatocellular carcinoma development (B09*)

• Subject Area: Immunology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 403224013

Hepatocellular carcinoma (HCC) is the most common primary malignant liver tumour and strongly driven by environmental factors. Project B09 dissects the microbiota-dependent and independent functions of inflammasome-mediated immunity during HCC development. Our experiments will reveal novel strategies to harness intestinal microbiota and inflammasome signalling for future HCC therapy and prevention.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1382: Gut-liver axis – Functional circuits and therapeutic targets
• Applicant Institution: Rheinisch-Westfälische Technische Hochschule Aachen
• Project Head: Professor Dr. Kai Markus Schneider