Molekulare Mechanismen der Aktivierung eosinophiler Granulozyten durch Interleukin-4 und Interleukin-13 beim Asthma bronchiale

• Applicant: Privatdozent Dr. Werner Luttmann
• Subject Area: Pneumology, Thoracic Surgery
• Term: from 2000 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 5226772

• Final Report Year: 2009

Final Report Abstract

No abstract available

Publications

• A microscale assay for the identification of TGF-ß antagonists based on functional coupling of the heterodimeric TGF-ß receptor to STAT6-driven promoter activation. Signal Transduction 4: 55-9 (2005)
  Krause, S.; Friedrich, K.
  
• Blockade of interleukin-13-mediated celt activation by a novel inhibitory antibody to human IL-13 receptor a 1. Mol. Immunol. 43:1799-807 (2006)
  Krause, S.; Behrends, J.; Borowski, A.; Lohrmann, J.; Lang, S.,; Myrtek, D.; Lorenzen, T.; Virchow, J.C.; Luttmann, W.; Friedrich, K.
  
• Specific inhibition of interleukin-13 activity by a recombinant human single-chain immunoglobulin domain directed against the IL-13 receptor alphal chain. Biol. Chem. 388:325-30 (2007)
  Knackmuss, S.; Krause, S.; Engel, K.; Reusch, U.; Virchow, J.C.; Mueller, T.; Kraich, M.; Little, M.; Luttmann, W.; Friedrich, K.
  
• Interleukin-13 promotes pro-fibrotic parameters in epithelia and fibroblasts of the human lung. Clin. Exp. Allergy 38:619-28 (2008)
  Borowski, A.; Kuepper, M.; Horn, U.; Knüpfer, U.; Zissel, G.; Höhne, K.; Luttmann, W.; Krause, S.; Virchow jr., J.C.; Friedrich, K.
  
• Safety of segmental allergen challenge in human allergic asthma. J Allergy Clin Immunol. 121:712- 72 (2008)
  Julius, P.; Lommatzsch, M.; Kuepper, M.; Bratke, K.; Faehndrich, S.; Luttmann, W.; Virchow, J.C.
  
• Alternatively activated alveolar macrophages in pulmonary fibrosis show charactristic patterns of chemokine/cytokine production and intracellular signal transduction. J. Leukocyte Biol.
  Pechkovsky, D.V.; Prasse, A.; Kollert, F.; Engel, K.; Luttmann, W.; Friedrich, K.; Müller-Quernheim, J.; Zissel, G.