Identification of molecular mechanisms involved in initial host-pathogen interaction in contagious bovine pleuropneumonia as potential therapeutic targets

• Applicants: Dr. Martin Heller; Privatdozent Dr. Robert Kammerer; Dr. Jochen Meens; Dr. Christiane Schnee
• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology ; Veterinary Medical Science
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 521734223

Therefore, we are particularly interested in this initial host-pathogen interaction that determines the outcome of the disease. In the present project, we will therefore investigate this important initial interaction of Mmm with the primary target cells of the host organism, both in vitro and in vivo, at the molecular level. In particular, we will elucidate the molecular basis of adhesion of the pathogen to the host cell. To this end, we will identify adhesins of Mmm and determine their cellular receptors. We will also study in detail the early response of host epithelial cells to contact with the pathogen. In addition, we will study the antibody response against molecules involved in the early phase of infection. The overall goal of this project is to better understand the molecular basis of the early interaction between pathogen and host. In doing so, we aim to identify target structures that may facilitate the development of new therapeutic tools.

• DFG Programme: Research Grants
• International Connection: Kenya
• International Co-Applicants: Victor Mobegi, Ph.D.; Martin Kiogora Mwirigi; Elise Schieck, Ph.D.