DNA-Facilitated Nano-assembly of Biological Block Co-polymers (R13)

• Subject Area: Biochemistry
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 464588647

We will investigate the extent to which disordered protein domains fused with transcription factors can be described as multi-block co-polymers, and study how the individual blocks and their sum tune function. Our studies will pair in vitro assays aimed at classifying and benchmarking solution and surface-mediated nano-assembly processes with in vivo quantitative tools based on high-resolution fluorescence methods to probe the number, spatial distribution and actual conformational states of the participating biopolymers inside living cells.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1551: Polymer Concepts in Cellular Function
• Applicant Institution: Johannes Gutenberg-Universität Mainz
• Project Heads: Dr. Martin Girard; Professor Dr. Edward A. Lemke; Dr. Sina Wittmann