The main objective of our project is to improve the molecular understanding of ADTKD, enabling us to design and validate interventional strategies in cellular and murine models. We aim to establish novel causative genes for ADTKD and thereby hope to gain more insights into disease mechanisms. Furthermore, we will generate and analyze patient-derived tubular cells by RNA-sequencing and metabolomics in order to identify novel pathway signatures. Finally, we will use patient-derived cells and murine models to validate interventional strategies (antisense oligonucleotides and BRD4780), principally suitable for clinical applications.
DFG Programme
CRC/Transregios
