Uromodulin-NET-complement interaction in tubulointerstitial injury
(C02)
Subject Area
Pathology
Nephrology
Term
since 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993
This project aims to investigate the role and interaction of uromodulin (UMOD), neutrophil extracellular traps (NET) and the complement system in inflammatory and non-inflammatory tubulointerstitial kidney disease. To this end, we will investigate the presence, abundance and interaction of these three factors and their effects on inflammatory processes, fibrosis and renal function in human kidney biopsies, animal and in vitro models. Using inhibitor and knockout strategies, we will assess whether modulation of UMOD-NET-complement interaction could represent a new therapeutic target in tubulointerstitial kidney disease.
DFG Programme
CRC/Transregios
