In the last funding period, we found that 2-oxoglutarate dioxygenase inhibitors (2OGDi) reduce inflammation in the mouse adenine nephropathy model. According to our results, we hypothesize that 2OGDi-mediated inflammasome-inhibition reduces chronic renal inflammation, which requires immunoregulatory and renoprotective effects of immunoregulatory Nr4a1-positive mononuclear phagocytes (MNPs). In this funding period, we will investigate the role of intracellular Ca2+ balance and adenylate cyclases on 2OGDi-mediated inflammasome inhibition and we will explore the role of Nr4a1-positive MNPs in 2OGDi-dependent renoprotection.
DFG Programme
CRC/Transregios
