Phenotypic and functional characterization of pro-fibrotic and pro-regenerative T cells in models of renal fibrosis (B04)

• Subject Area: Nephrology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

Fibrosis caused by repetitive injuries is considered a major cause of organ failure. We developed an experimental system to study repetitive renal insults and found strong evidence for the generation of a “fibrotic memory”. CD4+ memory T cells and IL-3 were identified as key players in this process. In the next funding period, we would like to better understand how these T cells are activated and what downstream pathways lead to matrix production. In addition, we will investigate whether there are also counterbalancing anti-fibrotic T cells and study the impact of sodium chloride on fibrosis development.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Head: Professor Dr. Matthias Mack