Fibrosis caused by repetitive injuries is considered a major cause of organ failure. We developed an experimental system to study repetitive renal insults and found strong evidence for the generation of a “fibrotic memory”. CD4+ memory T cells and IL-3 were identified as key players in this process. In the next funding period, we would like to better understand how these T cells are activated and what downstream pathways lead to matrix production. In addition, we will investigate whether there are also counterbalancing anti-fibrotic T cells and study the impact of sodium chloride on fibrosis development.
DFG Programme
CRC/Transregios
