LRP1 is an ubiquitously expressed membrane receptor that is involved in Wnt/β-catenin signaling and in cholesterol metabolism but also in modulation of immune cells. These mechanisms are all involved in the pathogenesis of acute kidney injury (AKI). Our preliminary experiments suggest LRP1 agonism as a plausible nephroprotective therapeutic approach corresponding to published data in myocardial infarct treatment. Thus, we will investigate the role of LRP1 in AKI as an experimental fundament for a clinical study.
DFG Programme
CRC/Transregios
