Cardio- and nephroprotective mechanisms of SGLT2 inhibition (A06)

• Subject Area: Cardiology, Angiology ; Anatomy and Physiology ; Nephrology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 509149993

SGLT2 inhibitors (SGLT2i) have substantial beneficial effects on renal and cardiac function but underlying mechanisms are unknown. We will investigate the role of cardiac Na+ channels for SGLT2i-dependent inhibition of cardiac injury, the impact of SGLT2i-improved ejection fraction for renal protection in mice with heart failure induced by transverse aortic constriction. Furthermore, we will identify molecular mechanisms of SGLT2i-induced microalbuminuria and renal myo-inositol loss and explore the consequences of these pathways for cardiac function in mice and patients with heart failure. The results will shed light on new mediators and mechanisms of cardio-renal crosstalk upon SGLT2i.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 374: Tubular system and interstitium of the kidney: (Patho-)physiology and crosstalk
• Applicant Institution: Universität Regensburg
• Project Heads: Professor Lars Maier; Dr. Philipp Tauber; Professor Dr. Stefan Wagner