In the previous funding period, we identified calcium-activated chloride secretion induced by HIF-1α and mediated by the chloride channel Anoctamin 1 as a significant contributor to cyst growth in polycystic kidney disease. In this funding period, we will address the impact of HIF-induced but secretion-independent signaling pathways on cyst progression in vitro and in vivo by inhibition of GLUT1-mediated glucose transport, use of approved HIF-PHD inhibitors, antagonism of IL-1 receptor signaling, application of the antioxidant coenzyme Q10, and inhibition of ferroptosis.
DFG Programme
CRC/Transregios
