Model-based reconciliation of ex vivo and in vivo test data (X01)

• Subject Area: Medical Physics, Biomedical Technology ; Mechanics
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 460333672

X01 targets the long-standing problem of contradicting results regarding the mechanical properties of ultrasoft matter such as brain tissue when using different ex vivo and in vivo testing techniques. Our hypothesis is that we can establish a continuum based model, which enables unifying the different experimentally observable regimes in vivo and ex vivo. Thus, we can for the first time use ex vivo mechanical parameters harvested from different testing modalities to explain the in vivo behaviour of the human brain.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1540: Exploring Brain Mechanics (EBM): Understanding, engineering and exploiting mechanical properties and signals in central nervous system development, physiology and pathology
• Applicant Institution: Friedrich-Alexander-Universität Erlangen-Nürnberg
• Project Heads: Professorin Dr. Jing Guo; Professor Dr. Ingolf Sack; Professor Dr.-Ing. Paul Steinmann; Professor Dr.-Ing. Kai Willner