Membrane determinants for ABC transporter plasticity (P11)

• Subject Area: Structural Biology ; Biochemistry ; Biophysics
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 467522186

This project will analyze the structure, dynamics and function of plasma membrane ABC transporters such as P-glycoprotein and aims to understand how these are regulated by their membrane environment. He will use cryo-electron microscopy to dissect how structural changes depend on lipid composition, curvature and lateral pressure to identify new membrane-encoded determinants of ABC transporter function.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1557: Functional Plasticity encoded by Cellular Membrane Networks
• Applicant Institution: Universität Osnabrück
• Project Head: Professor Dr. Arne Möller